New research published in JAMA Internal Medicine looks at the inverse relationship between coffee drinking and mortality. In this population-based study, researchers used baseline demographic data to estimate hazard ratios for coffee intake and mortality, and also looked at the potential effect of specific genes which are known to modify caffeine metabolism.
In Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank, Lotfield, Cornelis, and Caporaso seek to answer the question:
“Moderate coffee consumption has been inversely associated with mortality; however, does heavy intake, particularly among those with common genetic polymorphisms that impair caffeine metabolism, increase risk of mortality?”
To understand their research and find an interesting example of population-based genetic research, read the full article – and and enjoy your favorite caffeine beverage guilt-free while you read!
To learn more about these issues and other genetics topics, participate in the SMHS’s online Genetics Journal Club.
Image citation: Foong, C. (2012). coffee [Online image]. Available at https://www.flickr.com/photos/cherylfoong/8249906174