Gene therapy for transfusion-dependent beta thalassemia patients?

Can gene therapy eliminate the need for blood transfusions for patients with transfusion-dependent β thalassemia?

This article reports the results of two phase 1-2 studies studied on the use of a gene therapy.  In these studies, patients with transfusion-depenent β-thalassemia received gene therapy to assess if this therapy would substitute for the standard therapy, red-cell blood transfusions.  The researchers were assessing both the safety and the efficacy of this gene therapy.  You can read the results of this study in the New England Journal of Medicine.

Thompson, A. A., Walters, M. C., Kwiatkowski, J., Rasko, J. E., Ribeil, J. A., Hongeng, S., … & Moshous, D. (2018). Gene therapy in patients with transfusion-dependent β-thalassemiaNew England Journal of Medicine378(16), 1479-1493.

To learn more about this area of gene therapy, explore additional readings from Himmelfarb Library’s full-text collection:

  • Boulad F, Mansilla-Soto J, Cabriolu A, Rivière I, Sadelain M. Gene Therapy and
    Genome Editing
    . Hematol Oncol Clin North Am. 2018 Apr;32(2):329-342. doi:
    10.1016/j.hoc.2017.11.007. Epub 2018 Jan 9. Review. PubMed PMID: 29458735.
  • Ferrari G, Cavazzana M, Mavilio F. Gene Therapy Approaches to
    Hemoglobinopathies
    . Hematol Oncol Clin North Am. 2017 Oct;31(5):835-852. doi:
    10.1016/j.hoc.2017.06.010. Review. PubMed PMID: 28895851.
  • Glaser A, McColl B, Vadolas J. The therapeutic potential of genome editing for
    β-thalassemia
    . F1000Res. 2015 Dec 11;4. pii: F1000 Faculty Rev-1431. doi:
    10.12688/f1000research.7087.1. eCollection 2015. Review. PubMed PMID: 26918126;
    PubMed Central PMCID: PMC4753996.

Explore more of Himmelfarb Library’s genetics collection by checking out:

Posted in Health news, Journals | Leave a comment

Who is talking about your research?

plumx
PlumX metrics are now available in Himmelfarb Library‘s Research Commons, a repository of research output for GW’s Milken Institute School of Public Health, the School of Medicine and Health Sciences, and the School of Nursing.

PlumX provides non-traditional  metrics  like Altmetric (social media shares, mentions, etc.), as well as more traditional metrics including  citation indexes. PlumX provides information about what’s happening with research post-publication including usage, captures, mentions, social media, and citations.

To get an idea of what PlumX can tell you about an article, check out this article by GW faculty published last year and mouse over the PlumX Metrics button on the right side of the screen:
 
 
If you have questions regarding the Research Commons, please contact Meaghan Heselden (corbettm@email.gwu.edu).
Posted in Databases, Faculty publications, Scholarly publishing | Leave a comment

New Resource: DNP Project Repository

GW-Nursing_logo_homepageA new Doctor of Nursing Practice (DNP) Project Repository recently was developed by the School of Nursing in collaboration with Himmelfarb Library‘s Research Commons.

The DNP Project Repository archives all doctoral projects completed within GW’s DNP program. It is used to advance nursing practice by preserving, archiving, and sharing these projects in a permanent digital archive even after student graduation. In addition, the repository can assist current and future DNP students in developing their own projects.

The repository is an open-access site that is searchable and discoverable via search engines.  Students retain copyright of their work and receive a unique, persistent URL that can be shared with colleagues and added to their CV/resume.

The DNP Project Repository was pilot tested in October 2017 with several 2017 DNP graduates. The Repository has now gone live and DNP students graduating in May 2018 are in the process of submitting their projects.

Be sure to check them out at hsrc.himmelfarb.gwu.edu/son_dnp/.
Posted in Databases, Faculty publications, Scholarly publishing | Leave a comment

Wipe out your fines – give food for fines!

Have library fines?  Participate in our Food for Fines Drive!

476.1996.1

Until May 25th, for every non-perishable item you bring to the Circulation Desk, you can clear a dollar off your fines!  All items will be donated to The Store, a student-run food pantry at GW.

Clear out your pantry, settle up your fines, and help people in need!

image: https://www.google.com/search?q=moma+tomato+soup&tbm=isch&tbo=u&source=univ&sa=X&ved=0ahUKEwj5xfHfv73TAhWF4CYKHfzOA0EQiR4IjAE&biw=1406&bih=912#imgrc=JnowrUJNYro3IM:
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What’s happening in May? Flowers, embassies…and a parade!

May 2018 DC Events

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PolicyMap now available @ Himmelfarb!

policymapPolicyMap is now available via Himmelarb Library!
PolicyMap allows users to create maps by combing access to a data library with mapping and reporting tools.  PolicyMap provides access to more that 150 data sources and also allows users to upload their own data.  Users can then create maps, generate reports, and run analytics.
To learn more about PolicyMap, you can look at PolicyMap YouTube Channel or check out tutorials including:
  • Maps: easily display data using different geographic parameters
  • Tables: View data as a bar graph or chart to compare multiple geographies
  • Reports: Run reports for predefined geographic areas or create a custom area
  • 3-Layer maps: Find areas that meet up to three criteria for site selection or to locate hot spots
  • Data loader: updaload your own address-level data
  • Data download: download PolicyMap data for use in your research
PolicyMap is available from on- and off-campus locations.  Off-campus users can access PolicyMap via either VPN or web-based login.  If you have questions, please contact Laura Abate (leabate@gwu.edu).
Posted in Databases, Software/Multimedia | Leave a comment

GW Research Days: The Videos!

researchdayvideosWant to learn about projects from GW’s Research Days 2018?  Watch the videos!

Each year, GW Research Days provides a showcase for research and scholarship occurring at The George Washington University.  Over two days, faculty and undergraduate, graduate, and postdoctoral students showcase their research and highlight the scope of research occurring at GW.

Himmelfarb Library interviewed eighteen GW Research Days presenters.  Watch the videos to learn more about health sciences research at GW!
Posted in Faculty publications, Scholarly publishing, Special events | Leave a comment